Newsletter Celestamine Celestamine belongs to the steroid family drugs and it contains Betamethasone and dexchlorpheniramine maleate as active ingredients. Celestamine (Betamethasone/dexchlorpheniramine) is commonly used to treat hypersensitivity or allergic reactions and inflammatory conditions. Buy Celestamine Online Mechanism of action Betamethasone which is an active ingredient of Celestamine is a synthetic glucocorticoid (steroids) with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to a specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression which induced the synthesis of certain anti-inflammatory proteins while the synthesis of some inflammatory mediators is reduced. Therefore Betamethasone causes overall reduction in autoimmune reactions and chronic inflammation, thus reduces natural immune response of the body. Dexchlorpheniramine is an alkylamine, and first-generation histamine receptor antagonist with anti-allergic activity. Dexchlorpheniramine competitively antagonises H1 receptors, thereby inhibiting the actions of histamine on H1 Histamine receptors on bronchial smooth muscle, capillaries and gastrointestinal smooth muscle. The antagonistic action of Dexchlorpheniramine inhibits the actions of endogenous histamine, thereby preventing histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms, therefore used to treat allergic conditions such as hay fever or urticaria.  We’ve discussed the pharmacology of most common & essential drugs, & their Mechanism of actions, contraindications, cautions, side effects, use in pregnancy, use in breast feeding, adult dose, pediatric dose in our Pharmacology Made Easy eBook.  Download Now Betamethasone is used as an ingredient of Celestamine in some countries such as :  Brazil Chile Hong Kong Indonesia Japan Paraguay Philippines South Africa Venezuela Dexchlorpheniramine is used as an ingredient of Celestamine in Hong Kong. Buy Celestamine Online Indications / Diseases where Celestamine is used: Perennial allergic rhinitis Severe bronchial asthma Serum sickness Hay fever (pollenosis) Drug reactions Atopic dermatitis (eczema) Contact dermatitis Inflammatory ocular disorders Iridocyclitis Uveitis Keratitis Conjunctivitis Non-granulomatous iritis Chorioretinitis and Choroiditis Celestamine Dosage Dose of Celestamine depends on the patient’s response to the drug and the severity of the illness. In the case, the conditions are better; the dosage should be reduced little by little until it is reduced to a minimum. After reaching the lowest dose, it should be suspended slowly. For people older than 12 years, an initial dose of 1 or 2 tablets (1 or 2 tablespoons) is prescribed for four times a day. It is best to take the dose after a filling meal or at bedtime. Do not increase the dose of Celestamine Ns in more than eight tablets or 8 tablespoons in the case of Celestamine Ns syrup. For children between 6 and 12 years, a dose of ½ tablet (1/2 tablespoon) should be administered three times a day. The dose should not exceed more than 4 tablets or 4 tablespoons in the case of syrup. For children between 2 and 6 years old, a dose of ¼ or ½ tablespoon should be administered three times a day. The general dosage should not be more than two tablespoons. Summary of Celestamine dosage : Age Dose Frequency Maximum Dose >12 years 1 or 2 tablets (1 or 2 tablespoons) 4 times/day 8 tablets or 8 tablespoons 6 – 12 years ½ tablet (1/2 tablespoon) 3 times/day 4 tablets or 4 tablespoons 2 – 6 years ¼ or ½ tablespoon 3 times/day 2 tablespoons Buy Celestamine Online Special precautions If celestamine contains Betamathasone : As it contains Betamethasone as an active ingredient, adjustments of dosages in both adults and children may be required with remission or exacerbation of the clinical condition. Also, we should consider each patient’s individual response to therapy and exposure of the patient to psychological or physical stress such as injury, surgery or serious infection. Betamethasone is a Corticosteroid, so we should monitor the patient for at least up to one year following the discontinuation of long-term or high-dose corticosteroid therapy. Since complications of glucocorticoid therapy are dependent on duration and dosage of treatment, doctor should make the decision of risk or benefit for with each patient and their associated comorbidities. Since high dose or long-term corticosteroid therapy is associated with many side effects like osteoporosis (fragile bones), hypertension (high blood pressure), diabetes etc. the lowest possible dose of corticosteroid should be used to control the condition under treatment. A gradual reduction of dosage is recommended. When the drugs are used in patients who have other comorbidities like hypothyroidism and cirrhosis, adverse effects of corticosteroids are increased. Patients who take corticosteroids should be cautious if it’s used in patients with ocular herpes simplex because of possible risk of corneal perforation. Psychological derangements also reported with corticosteroid therapy and those who already have emotional instability or psychotic tendencies may be aggravated by corticosteroid drugs like betamethasone/celestamine preparations. These drugs should be used with caution conditions such as diverticulitis, fresh intestinal anastomoses, nonspecific ulcerative colitis, if there is a possible impending perforation, other pyogenic infection, abscess, or active or latent peptic ulcer disease, myasthenia gravis, osteoporosis, hypertension and renal insufficiency. Since Corticosteroids are immunosuppressive agents, they may mask some signs of ongoing infection, and new infections may also appear during use. When corticosteroids are used, decreased resistance and inability to localize infection may occur. Prolonged use of corticosteroid may lead to glaucoma with possible damage to the optic nerves, posterior subcapsular cataracts (mainly in children) and may increase the chance of secondary ocular infections due to fungi or viruses. Elevation of blood pressure, retention of salt and water, and increased excretion of potassium which lead to hypokalemic complications may also occur with average and large doses of corticosteroids. However, these side effects are less likely to occur when synthetic derivatives of corticosteroids are used except when used in large doses. Supplementation of potassium and restriction of Dietary salt may be considered for these patients. All corticosteroids will increase excretion of calcium. So, it’s advised to take calcium supplements or calcium rich foods to prevent complications that can occur with long term calcium deficiency. Since corticosteroids have immunosuppressive actions, patients should never be vaccinated for small pox. Other immunization procedures also should never be undertaken in patients who receive treatments with corticosteroids like betamethasone,